SML0630

JW55

≥98% (HPLC)

• Synonym(e): N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
• Empirische Formel (Hill-System): C₂₅H₂₆N₂O₅
• CAS-Nummer: 664993-53-7
• Molekulargewicht: 434.48
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N(CC4(CCOCC4)c3ccc(cc3)OC)C(=O)c1ccc(cc1)NC(=O)c2[o]ccc2
• InChI: 1S/C25H26N2O5/c1-30-21-10-6-19(7-11-21)25(12-15-31-16-13-25)17-26-23(28)18-4-8-20(9-5-18)27-24(29)22-3-2-14-32-22/h2-11,14H,12-13,15-17H2,1H3,(H,26,28)(H,27,29)
• InChI key: ZJZWZIXSGNFWQQ-UHFFFAOYSA-N

Beschreibung

Application

JW55 has been used as a tankyrase-specific inhibitor to study its effects on the transcriptional activity of SRY-related HMG-box gene 9 (Sox9) in chondrocytes.

Biochem/physiol Actions

JW55 is a potent and selective inhibitor of Wnt/β-catenin signaling, that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2

JW55 is a potent and selective inhibitor of Wnt/β-catenin signaling, that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2) leading to stabilization of AXIN2 followed by increased degradation of β-catenin. JW55 specifically inhibits canonical Wnt signaling that results in reduced cell-cycle progression, proliferation, and colony formation in colon carcinoma cell lines.

JW55 can decrease the formation of mouse colon adenoma in vivo. It possesses a methoxyphenyl moiety spreading towards the G-loop.

Other Notes

JW55 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the JW55 probe summary on the Chemical Probes Portal website.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable