SML0493

T16Ainh-A01

≥95% (HPLC)

• Synonym(e): 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide
• Empirische Formel (Hill-System): C₁₉H₂₀N₄O₃S₂
• CAS-Nummer: 552309-42-9
• Molekulargewicht: 416.52
• NACRES: NA.77
• PubChem Substance ID: 329825443
• UNSPSC Code: 12352200
• MDL number: MFCD03278952
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O
• InChI: 1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
• InChI key: QSIYTNYMBWYHAA-UHFFFAOYSA-N

Beschreibung

Application

T16Ainh-A01 has been used as an inhibitor of transmembrane protein 16A (TMEM16A).

Biochem/physiol Actions

T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.

T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor...

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable