SML0300

Aib-1 trifluoroacetate salt

≥98% (HPLC)

• Synonym(e): Tyr-Aib-Trp-Phe trifluoroacetate salt
• Empirische Formel (Hill-System): C₃₃H₃₇N₅O₆ · xC₂HF₃O₂
• CAS-Nummer: 1334763-90-4
• Molekulargewicht: 599.68 (free base basis)
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329825306
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: lyophilized solid
• Farbe: white to beige
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: OC(=O)C(F)(F)F.CC(C)(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2cc3ccccc3[nH]2)C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C33H37N5O6.C2HF3O2/c1-33(2,38-29(40)25(34)16-21-12-14-24(39)15-13-21)32(44)37-27(19-23-18-22-10-6-7-11-26(22)35-23)30(41)36-28(31(42)43)17-20-8-4-3-5-9-20;3-2(4,5)1(6)7/h3-15,18,25,27-28,35,39H,16-17,19,34H2,1-2H3,(H,36,41)(H,37,44)(H,38,40)(H,42,43);(H,6,7)/t25-,27-,28-;/m0./s1
• InChIKey: NELSAMPJZPTPEG-MDQBHWJISA-N

Beschreibung

Biochem./physiol. Wirkung

Aib-1 is an inhibitor of β-Amyloid oligomerization.

Aib-1 is an inhibitor of β-Amyloid oligomerization. Aib-1 is an endomorphin analog more stable to enzymatic degradation and incorporating the β-breaker 2 aminoisobutyric acid. It interacted with Aβ and markedly inhibited the formation of toxic oligomer and fibril growth using in vitro assays, prevented Aβ toxicity in neuronal PC12 cells, and increased longevity in a fly model of Alzheimer′s disease. Aib-1 activity is thought to be due to multi-mode interactions including aromatic, hydrophobic, and polar contacts with Aβ.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable