SML0277

Methylnaltrexon

≥97% (HPLC), narcotic antagonist, powder

• Synonym(e): (17RS)-17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinaniumbromid, N-Methylnaltrexon, MNTX, Methylnaltrexon, Mrz-2663, Naltrexon-Methobromid, Quartäres Ammoniumderivat von Naltrexon
• Empirische Formel (Hill-System): C₂₁H₂₆NO₄ · Br
• CAS-Nummer: 73232-52-7
• Molekulargewicht: 436.34
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825285
• NACRES: NA.77
• MDL number: MFCD06407831
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: Methylnaltrexon, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: ≥5 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [Br-].C[N@+]1(CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@]2(O)CCC4=O)c35)CC6CC6
• InChI: 1S/C21H25NO4.BrH/c1-22(11-12-2-3-12)9-8-20-17-13-4-5-14(23)18(17)26-19(20)15(24)6-7-21(20,25)16(22)10-13;/h4-5,12,16,19,25H,2-3,6-11H2,1H3;1H/t16-,19+,20+,21-,22?;/m1./s1
• InChI key: IFGIYSGOEZJNBE-KNLJMPJLSA-N
• Gene Information: human ... OPRM1(4988)

Beschreibung

General description

Methylnaltrexone does not cross blood brain barrier and does not affect the opioid effects in the brain, such as analgesia. It is used to treat opioid-induced constipation (OIC).

Application

Methylnaltrexone bromide has been used as a drug to measure plasma protein binding (PPB), permeability (Pm) and the membrane coefficient (KIAM) for the prediction of blood brain barrier (BBB) penetration. It is also used as a mu-opioid receptor (MOR) antagonist to abrogate morphine tolerance and opioid-induced hyperalgesia (OIH).

Biochem/physiol Actions

Methylnaltrexonbromid ist ein narkotischer Antagonist.

Methylnaltrexonbromid ist ein narkotischer Antagonist. Es ist ein peripher wirkender μ-Opioidrezeptor-Antagonist, der die Blut-Hirn-Schranke nicht überqueren kann. Es reversiert viele Nebenwirkungen von Opioiden, ohne die Schmerzlinderung zu beeinflussen.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Warning
• hcodes: H371
• pcodes: P260 - P264 - P270 - P308 + P311 - P405 - P501
• Hazard Classifications: STOT SE 2 Oral
• target_organs: Gastrointestinal tract
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable