SML0147

Drospirenon

≥98% (HPLC)

• Synonym(e): 6β,7β:15β,16β -Dimethylen-3-oxo-17α-pregn-4-en-21,17-carbolacton, Dihydrospirorenon
• Empirische Formel (Hill-System): C₂₄H₃₀O₃
• CAS-Nummer: 67392-87-4
• Molekulargewicht: 366.49
• NACRES: NA.77
• PubChem Substance ID: 329825195
• UNSPSC Code: 51111800
• EC Number: 266-679-2
• MDL number: MFCD00867350
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -180 to -195°, c = 1 in methanol
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥15
• originator: Bayer
• storage temp.: 2-8°C
• SMILES string: C[C@]12CCC(=O)C=C1[C@@H]3C[C@@H]3[C@@H]4[C@@H]2CC[C@@]5(C)[C@H]4[C@@H]6C[C@@H]6[C@@]57CCC(=O)O7
• InChI: 1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1
• InChI key: METQSPRSQINEEU-HXCATZOESA-N
• Gene Information: human ... NR3C2(4306), PGR(5241)

Beschreibung

Application

Drospirenone was tested for genotoxicity in rat and human hepatocytes.[1]

Drospirenone has been used as a progestogen agent in pond snail and fish.[2]

Biochem/physiol Actions

Drospirenon ist ein Progestin der vierten Generation mit antimineralcorticoider und antiandrogener Aktivität, sowie starker Progestagenaktivität. Zwei aktuelle Studien zeigen, dass Drospirenon das Risiko von venösen Thromboembolien, im Vergleich zu Levonorgestrel, verdoppeln soll, obwohl andere Studien wenig zusätzliches Risiko fanden.

Gestagen der vierten Generation, Kontrazeptivum

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H360
• Hazard Classifications: Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501