SML0076

Zoniporide hydrochloride hydrate

≥98% (HPLC), sodium-hydrogen exchanger isoform 1 (NHE-1) inhibitor, powder

• Synonym(e): N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate
• Empirische Formel (Hill-System): C₁₇H₁₆N₆O · xHCl · yH₂O
• CAS-Nummer: 241800-98-6
• Molekulargewicht: 320.35 (anhydrous free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825138
• NACRES: NA.77
• MDL number: MFCD04113213
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: Zoniporide hydrochloride hydrate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
• InChI: 1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
• InChI key: UCIJUEGJEFJRMP-UHFFFAOYSA-N

Beschreibung

Application

Zoniporide hydrochloride hydrate may be used in Na⁺/H⁺-mediated cell signaling studies.

Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.[1]

Biochem/physiol Actions

Potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1)

Zoniporide is a potent and selective inhibitor of Na⁺/H⁺ exchanger isoform 1 (NHE-1). IC₅₀ = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na⁺ update with IC₅₀ of 14 nM.

Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults.[2] It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats.[3] Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.[4]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable