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SCP0110
Cathepsin L Inhibitor
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5 MG
€ 108,00
€ 108,00
Versand in der Regel in 2 Wochen.
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5 MG
€ 108,00
About This Item
Empirische Formel (Hill-System):
C35H59N11O5
Molekulargewicht:
713.91
UNSPSC-Code:
12352200
NACRES:
NA.32
€ 108,00
Versand in der Regel in 2 Wochen.
Empfohlene Produkte
Assay
≥95% (HPLC)
Form
lyophilized
Zusammensetzung
Peptide Content, ≥55%
Lagerbedingungen
protect from light
Lagertemp.
−20°C
Amino Acid Sequence
Arg-Lys-Leu-Leu-Trp-NH2
Allgemeine Beschreibung
Cathepsin L Inhibitor is a histone H3-processing enzyme.[1] It is important for maintaining epidermal homeostasis, regular hair follicle morphogenesis and cycling.[2] Cathepsin L is involved in protein degradation.[3] It might regulate normal functioning of the immune system.[2] Cathepsin L regulates the death of macrophages, necrotic core formation and development of atherosclerotic plaque instability.[4]
Anwendung
Cathepsin L is a lysosomal cysteine proteinase that metabolizes collagens and elastins. The roles and activity of Cathepsin L can be studied with the aid of peptide inhibitors such as the pentapeptide amide RKLLW-NH2 (Arg-Lys-Leu-Leu-Trp-NH2).
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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A Brinker et al.
European journal of biochemistry, 267(16), 5085-5092 (2000-08-10)
By screening a combinatorial pentapeptide amide collection in an inhibition assay, we systematically evaluated the potential of 19 proteinogenic amino acids and seven nonproteinogenic amino acids to serve as building blocks for inhibitors of human cathepsin L. Particularly efficient were
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
Liu J, et al.
Atherosclerosis, 184(2), 302-311 (2006)
Protease signalling: the cutting edge
Turk B, et al.
The Embo Journal, 31(7), 1630-1643 (2012)
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis
Li W, et al.
Atherosclerosis, 202(1), 92-102 (2009)
V Turk et al.
The EMBO journal, 20(17), 4629-4633 (2001-09-05)
From their discovery in the first half of the 20th century, lysosomal cysteine proteases have come a long way: from being the enzymes non-selectively degrading proteins in lysosomes to being those responsible for a number of important cellular processes. Some
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Do you have any references for product SCP0110, Cathepsin L Inhibitor?
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Product SCP0110, Cathepsin L inhibitor peptide has the sequence Arg-Lys-Leu-Leu-Trp-NH2, which can be abbreviated RKLLW-NH2.See the following paper for reference: A. Brinker, et al.: Eur. J. Biochem., 267(16), 5085-5092 (2000). Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections.
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