SAB5702988

Anti-RNF20 Antibody, clone 8N4O8, Rabbit Monoclonal

• Synonym(e): BRE1, BRE1A, hBRE1
• UNSPSC-Code: 12352203
• NACRES: NA.46
• Klon: 8N4O8, monoclonal
• application: WB
• Speziesreaktivität: mouse, mouse
• Methode(n): western blot: 1:500 - 1:2000

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Materialien: colorless
• Klon: 8N4O8, monoclonal
• Form: liquid
• Mol-Gew.: 120 kDa
• Speziesreaktivität: mouse, mouse
• Konzentration: 0.65 mg/mL
• Methode(n): western blot: 1:500 - 1:2000
• Farbe: colorless
• Isotyp: IgG
• Immunogene Sequenz: MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQF
• UniProt-Hinterlegungsnummer: Q5VTR2
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... RNF20(56254)

Beschreibung

Allgemeine Beschreibung

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RNF20 (Q5VTR2).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Anwendung

WB

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1