SAB4300259

Anti-phospho-AKT1/AKT2/AKT3 (pTyr³¹⁵/pTyr³¹⁶/pTyr³¹²) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-AKT antibody produced in rabbit, Anti-DKFZp434N0250 antibody produced in rabbit, Anti-PKBB antibody produced in rabbit, Anti-v-akt murine thymoma viral oncogene homolog 1 / 2 / 3 (protein kinase B, gamma) antibody produced in rabbit
• MDL-Nummer: MFCD03096597
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: ~60 kDa
• Speziesreaktivität: human, rat, mouse
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotyp: IgG
• Immunogene Sequenz: (P-E-YP-L-A)
• NCBI-Hinterlegungsnummer: NP_001014431.1; NP_001617.1; NP_005456.1
• UniProt-Hinterlegungsnummer: P31751
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pTyr315/pTyr316/pTyr312)
• Angaben zum Gen: human ... AKT1(207) , AKT2(208) , AKT3(10000)

Beschreibung

Immunogen

Peptide sequence around phosphorylation site of tyrosine 315/316/312 (P-E-Y(p)-L-A), according to the proteins AKT1/AKT2/AKT3.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. /IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.

Physikalische Form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable