SAB4200667

Anti-MR−Pro ADM (Internal) antibody produced in rabbit

affinity isolated antibody

• Synonym(e): mid regional pro−ADM
• UNSPSC-Code: 51111800

Eigenschaften

• Biologische Quelle: rabbit
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Form: buffered aqueous solution
• Mol-Gew.: ~5 kDa
• Speziesreaktivität: human
• Konzentration: ~1 mg/mL
• Methode(n): immunoblotting: 0.25-0.5 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92); immunohistochemistry: 20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas or placenta sections
• UniProt-Hinterlegungsnummer: P35318
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ADM(133)

Beschreibung

Allgemeine Beschreibung

MR-pro-ADM (mid-regional-pro-adrenomedullin) is a 47-residue long peptide, produced during posttranslational processing of adrenomedullin. It has a molecular weight of 5.1kDa. Adrenomedullin (ADM) is a vasodilator peptide which is produced and released by a wide variety of cells such as, macrophages, fibroblasts, cardiomyocytes etc. MR-pro-ADM functions as a substitute marker for ADM. This peptide is coded by the gene localized to human chromosome 11p15.4 which is composed of four exons and three introns.

Spezifität

Anti-MR-Pro ADM (Internal) recognizes human MR-Pro ADM.

Immunogen

synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM)

Biochem./physiol. Wirkung

In hemodialysis patients increased plasma levels of MR-pro-ADM (mid-regional-pro-adrenomedullin) is linked with decreased survival. This is due to increased vasodilation in response to higher levels of MR-pro-ADM; lower levels of this peptide result in increased vasoconstriction and hence, better prognosis. This peptide is also associated with increased cardiovascular mortality in dialysis patients. In type II diabetic patients, MR-pro-ADM peptide is linked with renal outcome, as adrenomedullin (ADM) gene regualates susceptibility to nephropathic progression.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Lagerung und Haltbarkeit

For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable