SAB3500112

Anti-MIMITIN antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-Assembly factor 2, Anti-MMTN, Anti-NADH dehydroxygenase (ubiquinone) 1 alpha subcomplex, Anti-NDUFA12L, Anti-NDUFAF2
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Methode(n): immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_777549
• UniProt-Hinterlegungsnummer: Q8N183
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... NDUFAF2(91942)

Beschreibung

Immunogen

Mimitin antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Mimitin.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kB-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.

Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500112.

Physikalische Form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable