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S8567

Sigma-Aldrich

SU 4312

≥98% (HPLC)

Synonym(e):

3-(4-Dimethylaminobenzylidenyl)-2-indolinone, 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture

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About This Item

Empirische Formel (Hill-System):
C17H16N2O
CAS-Nummer:
5812-07-7
Molekulargewicht:
264.32
MDL-Nummer:
MFCD00118147
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24278803
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

orange

Löslichkeit

DMSO: >10 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23

InChI

1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+

InChIKey

UAKWLVYMKBWHMX-RVDMUPIBSA-N

Angaben zum Gen

human ... FLT1(2321)

Anwendung

SU 4312 was used to study angiogenesis during development of zebrafish embryos.2

Biochem./physiol. Wirkung

SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1
SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sonstige Hinweise

This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Andreas Vogt et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 238(3), 656-663 (2009-02-25)
Presently, the zebrafish is the only vertebrate model compatible with contemporary paradigms of drug discovery. Zebrafish embryos are amenable to automation necessary for high-throughput chemical screens, and optical transparency makes them potentially suited for image-based screening. However, the lack of
Wei Cui et al.
British journal of pharmacology, 168(5), 1201-1214 (2012-10-16)
SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative disorders. In this study, we assessed neuroprotection by SU4312 against 1-methyl-4-phenylpyridinium

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