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S6377

Sigma-Aldrich

Sulfisoxazol

≥99.0%

Synonym(e):

4-Amino-N-(3,4-dimethyl-5-isoxazolyl)-benzolsulfonamid, N1-(3,4-Dimethylisoxazol-5-yl)-sulfanilamid, Sulfafurazol

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About This Item

Empirische Formel (Hill-System):
C11H13N3O3S
CAS-Nummer:
127-69-5
Molekulargewicht:
267.30
Beilstein:
6737262
EG-Nummer:
204-858-9
MDL-Nummer:
MFCD00003150
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24899697

Assay

≥99.0%

Löslichkeit

acetone: complete 50 mg/ml
10% HCl: complete 33 mg/mL, clear, colorless to faintly yellow
alcohol: slightly soluble
chloroform: insoluble

Ersteller

Roche

Lagertemp.

2-8°C

SMILES String

Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C

InChI

1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3

InChIKey

NHUHCSRWZMLRLA-UHFFFAOYSA-N

Angaben zum Gen

rat ... Ednra(24326)

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Anwendung

Sulfisoxazole was one of the antibiotics tested on bacterial reporter panel that gave information on pollution load on the environment.11

Biochem./physiol. Wirkung

Sulfisoxazole, a sulfonamide, is an antibacterial agent that acts by inhibiting the folic acid metabolism.1 It is also a non-selective endothelin antagonist. It is effective in the treatment of recurrent acute otitis media and also in rendering protection to retina against ischemic-like insults.2,3

Leistungsmerkmale und Vorteile

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Hanne T Soligard et al.
Pediatric research, 67(6), 614-618 (2010-03-11)
Ibuprofen binds to plasma albumin and could interfere with the binding of bilirubin in jaundiced newborn infants. Most clinical studies have not shown increased concentrations of unbound bilirubin (UB) in plasma from infants treated with ibuprofen for a patent ductus
Katrijn Cobbaut et al.
Foodborne pathogens and disease, 8(6), 719-724 (2011-03-09)
During a Escherichia coli O157 prevalence study on cattle farms, 324 E. coli O157 isolates were collected from 68 out of 180 cattle farms. All isolates harbored the eaeA gene and the enterohemolysin (ehxA) gene. The majority of the strains
B Ward et al.
Epidemiology and infection, 129(2), 287-293 (2002-10-31)
We investigated an outbreak of 54 cases of Salmonella Typhimurium phage type 9 (STM9) with a specific antibiotic resistance pattern. We used sequential analytic studies: two retrospective cohort studies, a case-control study, and a modified case-control study. An outbreak of
Charles E Ahlfors
The Journal of pediatrics, 144(3), 386-388 (2004-03-06)
Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in
Reply to 'Sulfisoxazole does not inhibit the secretion of small extracellular vesicles'.
Chan-Hyeong Lee et al.
Nature communications, 12(1), 976-976 (2021-02-14)
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