S5951

SW02

• Synonym(e): 4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester
• Empirische Formel (Hill-System): C₁₉H₂₃BrN₂O₅
• CAS-Nummer: 1010820-68-4
• Molekulargewicht: 439.30
• NACRES: NA.77
• PubChem Substance ID: 329824558
• UNSPSC Code: 12352200
• MDL number: MFCD17215960
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: powder
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)C1=C(C)N(CCCC(=O)OC)C(=O)NC1c2ccc(Br)cc2
• InChI: 1S/C19H23BrN2O5/c1-4-27-18(24)16-12(2)22(11-5-6-15(23)26-3)19(25)21-17(16)13-7-9-14(20)10-8-13/h7-10,17H,4-6,11H2,1-3H3,(H,21,25)
• InChI key: YFZRMRYVWWUQME-UHFFFAOYSA-N

Beschreibung

Application

SW02 may be used in Hsp70-mediated cell signaling studies.

Biochem/physiol Actions

SW02 is a specific activator/agonist of Hsp70.

SW02 is a specific activator/agonist of Hsp70. Hsp70 is of particular interest in diseases caused by protein misfolding, such as tau and Aβ in Alzheimer′s. SW02 increases Hsp70 ATPase activity, resulting in increased tau protein but not other disease-related proteins in cells. Hsp70 prevents aggregation of Aβ peptide, as shown by treatment with SW02.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301
• Sicherheitshinweise: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable