PZ0037

Crisaborole

≥98% (HPLC)

• Synonym(e): 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile, 5-(4-Cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole, 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole, AN2728
• Empirische Formel (Hill-System): C₁₄H₁₀BNO₃
• CAS-Nummer: 906673-24-3
• Molekulargewicht: 251.05
• MDL-Nummer: MFCD17169940
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: OB1OCC2=C1C=CC(OC3=CC=C(C#N)C=C3)=C2
• InChI: 1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
• InChIKey: USZAGAREISWJDP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Crisaborole is a non-steroidal anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor. Crisaborole has an IC₅₀ value of 490 nM for PDE4 with similar IC₅₀ values for release of cytokines TNF-α, IL-2, and IFN-γ, and shows little inhibition against other PDE isozymes. Crisaborole has been approved as a topical treatment for atopic dermatitis.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable