P9797

Pyridostigminbromid

• Synonym(e): 3-(Dimethylaminocarbonyloxy)-1-methylpyridiniumbromid
• Empirische Formel (Hill-System): C₉H₁₃BrN₂O₂
• CAS-Nummer: 101-26-8
• Molekulargewicht: 261.12
• EG-Nummer: 202-929-9
• MDL-Nummer: MFCD00079283
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277865
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Löslichkeit: water: 100 mg/mL, clear to very slightly hazy, colorless
• Ersteller: Valeant
• SMILES String: [Br-].CN(C)C(=O)Oc1ccc[n+](C)c1
• InChI: 1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
• InChIKey: VNYBTNPBYXSMOO-UHFFFAOYSA-M
• Angaben zum Gen: human ... ACHE(43)

Beschreibung

Anwendung

Pyridostigmine bromide has been used as a cholinesterase inhibitor in mice,[1] in florimetric assay for acetylcholine secretion[2] and for measuring acetylcholine release from mice atrial tissue.[3]

Biochem./physiol. Wirkung

Acetylcholinesterase Inhibitor.

Pyridostigmine bromide inhibits acetylcholine esterase and is membrane impermeable. It is used as a preventive medicine in chemical warfare.[4] Pyridostigmine bromide is a carbamate compound comprising quaternary amine structure. It displays low absorption at the gastrointestinal tract.[5] Sustained release of pyridostigmine is recommended for improving its bioavailability in treating myasthenia gravis.[6]

Leistungsmerkmale und Vorteile

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330,H317
• P-Sätze: P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
• Gefahreneinstufungen: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Skin Sens. 1
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges