P8861

Pyrrolnitrin

from Pseudomonas cepacia, ≥98% (HPLC), antibiotic, solid

• Synonym(e): 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole
• CAS-Nummer: 1018-71-9
• UNSPSC Code: 12352200
• PubChem Substance ID: 24898985
• NACRES: NA.77
• EC Number: 213-812-7
• MDL number: MFCD00865605
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Produktname: Pyrrolnitrin from Pseudomonas cepacia, ≥98% (HPLC), solid
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: solid
• antibiotic activity spectrum: fungi
• mode of action: enzyme | inhibits
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [O-][N+](=O)c1c(Cl)cccc1-c2c[nH]cc2Cl
• InChI: 1S/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H
• InChI key: QJBZDBLBQWFTPZ-UHFFFAOYSA-N

Beschreibung

Application

Pyrrolnitrin from Pseudomonas cepacia has been used as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract.

Biochem/physiol Actions

Pyrrolnitrin is a metabolite, produced by Pseudomonas sp.

Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.

The purified antibiotic has strong antifungal activity and is less efficient against bacteria or yeast.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves