P6628

Pilocarpin -nitrat (Salz)

≥98% (HPLC), muscarinic acetylcholine receptor agonist, powder

• Empirische Formel (Hill-System): C₁₁H₁₆N₂O₂ · HNO₃
• CAS-Nummer: 148-72-1
• Molekulargewicht: 271.27
• NACRES: NA.77
• PubChem Substance ID: 57654548
• UNSPSC Code: 12352200
• EC Number: 205-723-7
• MDL number: MFCD00078497
• Beilstein/REAXYS Number: 4171406
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Pilocarpin -nitrat (Salz), ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]25/D +83°, c = 10 in H₂O(lit.)
• color: white
• solubility: H₂O: 100 mg/mL
• SMILES string: O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
• InChI key: PRZXEPJJHQYOGF-GNAZCLTHSA-N
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Beschreibung

Application

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

Biochem/physiol Actions

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Nicht-selektiver muskarinischer Acetylcholin-Rezeptor Agonist.

Nicht-selektiver muskarinischer Acetylcholin-Rezeptoragonist, verwendet für ein experimentelles Epilepsiemodell.

Sicherheitshinweise

• pictograms: GHS03,GHS06
• signalword: Danger
• hcodes: H272,H302,H330
• pcodes: P210 - P220 - P260 - P264 - P301 + P312 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2
• Lagerklasse: 5.1B - Oxidizing hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges