P4668

Praziquantel

anthelminic, neurogenic

• Synonym(e): 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinolin-4-on
• Empirische Formel (Hill-System): C₁₉H₂₄N₂O₂
• CAS-Nummer: 55268-74-1
• Molekulargewicht: 312.41
• UNSPSC Code: 51452701
• NACRES: NA.85
• PubChem Substance ID: 24278635
• EC Number: 259-559-6
• Beilstein/REAXYS Number: 761557
• MDL number: MFCD00058531

Eigenschaften

• InChI key: FSVJFNAIGNNGKK-UHFFFAOYSA-N
• InChI: 1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
• SMILES string: O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
• form: powder or crystals
• antibiotic activity spectrum: parasites
• mode of action: cell membrane | interferes
• storage temp.: −20°C

Beschreibung

Application

Praziquantel is a potent anthelmintic used against schistosome and many cestode infestations. It is used to study voltage-gated Ca²⁺ channels and is a potential small molecule neurogenic[1].

Biochem/physiol Actions

Praziquantel increases the permeability of the tegmentum to Ca²⁺ which results in the contraction of schistosomes and death. Praziquantel causes vacuolization and disintegration of the schistosome tegument. It is more effective on adult worms than young worms. It inhibits glucose uptake, which lowers glycogen levels and stimulates lactate release. Praziquantel is a potent anthelmintic against parasitic flatworms (flukes and tapeworms). Recent studies have indicated that praziquantel binds to a varient of the β-subunit of the voltage gated Ca²⁺ channel and to actin, which is a component of some Ca²⁺ channels.

Other Notes

1g,5g,25g

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• hcodes: H412
• pcodes: P273 - P501
• Hazard Classifications: Aquatic Chronic 3
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• ppe: Eyeshields, Gloves, type N95 (US)