P3053

Penitrem A

≥95% (HPLC and TLC)

• Synonym(e): Tremortin A
• Empirische Formel (Hill-System): C₃₇H₄₄ClNO₆
• CAS-Nummer: 12627-35-9
• Molekulargewicht: 634.20
• NACRES: NA.77
• PubChem Substance ID: 24898385
• UNSPSC Code: 12352200
• MDL number: MFCD00083465
• Assay: ≥95% (HPLC and TLC)
• Form: powder

Eigenschaften

• Quality Segment: 200
• assay: ≥95% (HPLC and TLC)
• form: powder
• storage temp.: 2-8°C
• SMILES string: [H][C@]12CC[C@@]3(C)[C@@](O)(CC[C@@]4([H])[C@]5([H])OC(C)(C)[C@@]6([H])C[C@]7([H])C(=C)Cc8c(Cl)cc9[nH]c(c5c9c8[C@]67O)[C@]34C)[C@]1%10O[C@]%10([H])[C@@H](O)[C@H](O2)C(C)=C
• InChI: 1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1
• InChI key: JDUWHZOLEDOQSR-JKPSMKLGSA-N

Beschreibung

Application

Penitrem A has been used as Ca²⁺-Activated K⁺ (BK) channel blocker to study its effect on BK current in bag cell neurons.

Biochem/physiol Actions

Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Originally isolated from Penicillium palitans

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 2 Oral
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges