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P1038

Poly(cytidylic-inosinic) acid potassium salt

random copolymer

Synonym(e):

Poly (C,I)

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Über diesen Artikel

CAS-Nummer:
26301-44-0
UNSPSC Code:
41106305
NACRES:
NA.51
MDL number:
MFCD00167396
Form:
powder
Storage temp.:
−20°C

Quality Segment

200

form

powder

storage temp.

−20°C

Application

Poly(cytidylic-inosinic) acid potassium salt has been used:
  • in pretreatment to understand Con A-induced hepatitis in mice
  • in RNA extraction from hemolymph plasma for qPCR detection assay
  • to induce inflammatory changes in liver
  • as a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells

Biochem/physiol Actions

Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC). Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.
Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).

Other Notes

Random copolymer

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Questions

1–5 of 5 Questions  

  1. What can I use to solubilize Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?

    1 answer

    1. The product is soluble in water at 10 mg/mL.

      Helpful?

  2. Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, single or double stranded?

    1 answer

    1. Product No. P1038 is a single-stranded random co-polymer.

      Helpful?

  3. Will Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, work to induce interferon production?

    1 answer

    1. P1038 is a single stranded RNA. For cell activation, synthetic double-stranded RNA is widely used as the ligand of Toll-like receptor 3 (TLR3) in place of what is supposed to be the natural ligand (viral dsRNA). This would be Product No. P9582, a double stranded RNA homopolymer, i.e. Poly(I): Poly(C). This product is widely used by other satisfied customers for cell activation.

      Helpful?

  4. Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, product sterile?

    1 answer

    1. Product No. P1038 is not sterile. The product is produced in non-sterile conditions and the level of endotoxin content is not determined.

      Helpful?

  5. How large/long a polymer is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?

    1 answer

    1. The average length of this polynucleotide has not been determined.

      Helpful?

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