O2875

Orotsäure Kaliumsalz

≥98%

• Synonym(e): 6-Carboxy-2,4-dihydroxypyrimidine, Uracil-6-carboxylic acid
• Lineare Formel: C₅H₃N₂O₄K
• CAS-Nummer: 24598-73-0
• Molekulargewicht: 194.19
• NACRES: NA.51
• PubChem Substance ID: 24897970
• UNSPSC Code: 41106305
• EC Number: 246-341-0
• MDL number: MFCD00039118
• Assay: ≥98%
• Form: powder
• Solubility: 1 M NaOH: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow

Eigenschaften

• Quality Segment: 200
• assay: ≥98%
• form: powder
• solubility: 1 M NaOH: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: [K+].[O-]C(=O)C1=CC(=O)NC(=O)N1
• InChI: 1S/C5H4N2O4.K/c8-3-1-2(4(9)10)6-5(11)7-3;/h1H,(H,9,10)(H2,6,7,8,11);/q;+1/p-1
• InChI key: DHBUISJCVRMTAZ-UHFFFAOYSA-M

Beschreibung

Application

Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)