O2875

Orotsäure Kaliumsalz

Name: Orotsäure Kaliumsalz
Brand: SIGMA
Price: 176 EUR

≥98%

Synonym(e):

6-Carboxy-2,4-dihydroxypyrimidine, Uracil-6-carboxylic acid

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100 G

€ 176,00

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Über diesen Artikel

Lineare Formel:

C₅H₃N₂O₄K

CAS-Nummer:

24598-73-0

Molekulargewicht:

194.19

NACRES:

NA.51

PubChem Substance ID:

24897970

UNSPSC Code:

41106305

EC Number:

246-341-0

MDL number:

MFCD00039118

Assay:

≥98%

Form:

powder

Solubility:

1 M NaOH: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow

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Quality Level

200

assay

≥98%

form

powder

solubility

1 M NaOH: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

[K+].[O-]C(=O)C1=CC(=O)NC(=O)N1

InChI

1S/C5H4N2O4.K/c8-3-1-2(4(9)10)6-5(11)7-3;/h1H,(H,9,10)(H2,6,7,8,11);/q;+1/p-1

InChI key

DHBUISJCVRMTAZ-UHFFFAOYSA-M

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Dieser Artikel	O2750	C9375	A1757
Sigma-Aldrich O2875 Orotic acid potassium salt	Sigma-Aldrich O2750 Orotic acid	Sigma-Aldrich C9375 5-Carboxy-2-thiouracil	A1757 6-Azauracil
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
assay ≥98%	assay ≥98% (titration)	assay ≥98% (TLC)	assay ≥98%
form powder	form -	form powder	form powder
solubility 1 M NaOH: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow	solubility -	solubility 1 M NaOH: 50 mg/mL, clear, colorless to faintly yellow	solubility 1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green

Application

Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Lagerklasse

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The mechanisms of citrate on regulating the distribution of carbon flux in the biosynthesis of uridine 5'-monophosphate by Saccharomyces cerevisiae.

Yong Chen et al.

Applied microbiology and biotechnology, 86(1), 75-81 (2009-10-15)

A whole cell biocatalytic process for uridine 5'-monophosphate (UMP) production from orotic acid by Saccharomyces cerevisiae was developed. The concentration of UMP was increased by 23% when 1 g l(-1) sodium citrate was fed into the broth. Effects of citrate

Enhanced uridine 5'-monophosphate production by whole cell of Saccharomyces cerevisiae through rational redistribution of metabolic flux.

Liu D, Chen Y, Li A, Xie J, Xiong J, et al.

Bioprocess and Biosystems Engineering (2011)

Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase.

Ardala Breda et al.

Molecular bioSystems, 8(2), 572-586 (2011-11-15)

Tuberculosis (TB) is a chronic infectious disease caused mainly by Mycobacterium tuberculosis. The worldwide emergence of drug-resistant strains, the increasing number of infected patients among immune compromised populations, and the large number of latent infected individuals that are reservoir to

Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process.

Xing Wang et al.

Applied microbiology and biotechnology, 76(2), 321-328 (2007-05-24)

Attempts were made with success to develop a two-step biocatalytic process for uridine 5'-monophosphate (UMP) production from orotic acid by Corynebacterium ammoniagenes ATCC 6872: the strain was first cultivated in a high salt mineral medium, and then cells were harvested

Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver.

Eun-Jeong Jung et al.

Journal of lipid research, 52(9), 1617-1625 (2011-07-16)

Orotic acid (OA), an intermediate in pyrimidine metabolism, has been used for a variety of purposes, such as dietary supplements. Although it is well documented that OA induces fatty liver in a species-specific manner, the precise molecular mechanisms remain unclear.

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Global Trade Item Number

SKU	GTIN
O2875-100G	04061833049761

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Orotsäure Kaliumsalz