A1757

6-Azauracil

≥98%

• Synonym(e): 1,2,4-Triazin-3,5(2H,4H)-dion, 1,2,4-Triazin-3,5(2H,4H)-dion, 3,5-Dihydroxy-1,2,4-triazin
• Empirische Formel (Hill-System): C₃H₃N₃O₂
• CAS-Nummer: 461-89-2
• Molekulargewicht: 113.07
• Beilstein: 116472
• EG-Nummer: 207-318-0
• MDL-Nummer: MFCD00006456
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24890584
• NACRES: NA.51

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98%
• Form: powder
• mp (Schmelzpunkt): 274-275 °C (lit.)
• Löslichkeit: 1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green
• SMILES String: O=C1NN=CC(=O)N1
• InChI: 1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)
• InChIKey: SSPYSWLZOPCOLO-UHFFFAOYSA-N

Beschreibung

Anwendung

6-Azauracil has been used as a transcriptional inhibitor to study its effects on the deletion of termination and polyadenylation protein (Tpa1) and Mag1 on cell viability.[1] It has also been used as an orotidine-5′-monophosphate decarboxylase (OMPdecase) inhibitor in minimal media for determining the OMPdecase activity.[2]

Biochem./physiol. Wirkung

6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity.[3] It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP) and uridine triphosphate (UTP) nucleotide pools.[4]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves