O0383

N-Oleoylethanolamine

~98% (TLC), PPARα agonist, powder

• Synonym(e): N-(Hydroxyethyl)oleamide, N-(cis-9-Octadecenoyl)ethanolamine, OEA, oleoylethanolamide
• Empirische Formel (Hill-System): C₂₀H₃₉NO₂
• CAS-Nummer: 111-58-0
• Molekulargewicht: 325.53
• NACRES: NA.83
• PubChem Substance ID: 24278603
• UNSPSC Code: 12352204
• EC Number: 203-884-8
• MDL number: MFCD00045972

Eigenschaften

• Produktname: N-Oleoylethanolamine, ~98% (TLC)
• assay: ~98% (TLC)
• Quality Segment: 200
• form: powder
• solubility: chloroform: 20 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: O=C(CCCCCCC/C=C\CCCCCCCC)NCCO
• InChI: 1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
• InChI key: BOWVQLFMWHZBEF-KTKRTIGZSA-N
• Gene Information: human ... CNR1(1268), CNR2(1269), PPARA(5465), TRPV1(7442) ; mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

Beschreibung

General description

Oleoylethanolamide (OEA) is an endogenous fatty acid ethanolamine. Small intestine cells, adipose tissues, neurons and astrocytes produces OEA.

Application

N-Oleoylethanolamine has been used to study its effects on glucagon-like peptide (GLP)-1RA-mediated anorectic signaling and weight loss.

Biochem/physiol Actions

Oleoylethanolamide (OEA) is a lipid mediator, which helps to control various biological functions, like food intake. It modulates the gene expression in the small intestine. OEA has the ability to initiate several receptors, such as cannabinoid receptor type 1 (CB1), peroxisome proliferator-activated receptors (PPARs) and G protein-coupled receptor 119 (GPR119).

Peroxisome proliferator-activator receptor α (PPARα) agonist

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves