N7389

3-Nitro-L-Tyrosin

Oxidant, crystalline

• Lineare Formel: O₂NC₆H₃-4-(OH)CH₂CH(NH₂)CO₂H
• CAS-Nummer: 621-44-3
• Molekulargewicht: 226.19
• Beilstein/REAXYS Number: 2813157
• NACRES: NA.32
• PubChem Substance ID: 24897825
• eCl@ss: 32160406
• UNSPSC Code: 12352200
• EC Number: 210-688-6
• MDL number: MFCD00007123
• Form: crystalline

Eigenschaften

• Produktname: 3-Nitro-L-Tyrosin, crystalline
• form: crystalline
• Quality Segment: 200
• mp: 233-235 °C (dec.) (lit.)
• SMILES string: N[C@@H](Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O
• InChI: 1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1
• InChI key: FBTSQILOGYXGMD-LURJTMIESA-N

Beschreibung

Application

3-Nitro-L-tyrosine has been used in:

• western blot analysis to quantify the nitrotyrosine levels in mice tissue protein
• Murashige–Skoog medium to treat wild type and mitogen-activated protein kinase 6 (mpk6)-2 mutant seedlings for inferring the connection between nitric oxide (NO) and MPK6 functions in the regulation of mitotic microtubule organization
• immunocytochemistry

Biochem/physiol Actions

3-Nitro-L-tyrosine is an oxidant and cytotoxic agent. 3-Nitrotyrosine serves as a biological marker of proteins modified by nitrogen-free radical species in systemic autoimmunogenic conditions. It is a marker for oxidative damage mediated by peroxynitrite. Nitrotyrosine is associated with VEGF-C expression and lymph node metastasis in breast cancer. 3-Nitrotyrosine is produced due to oxidative/nitrosative stress-mediated chemical modifications such as nitration of proteins, which is observed in lung carcinogenesis.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)