Although the standard that has been tested is recombinant human renin, theoretically the kit should be suitable for all other species.
MAK157
Renin Assay Kit
Renin Assay Kit
1 of 1 reviewers received a sample product or took part in a promotion
sufficient for 100 fluorometric tests
Synonym(e):
Renin Enzyme Detection Kit
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1 KIT
€ 306,00
About This Item
UNSPSC-Code:
12161503
NACRES:
NA.84
Empfohlene Produkte
Verwendung
sufficient for 100 fluorometric tests
Nachweisverfahren
fluorometric
Relevante Krankheit(en)
cardiovascular diseases
Lagertemp.
−20°C
Angaben zum Gen
human ... REN(5972)
rat ... REN(24715)
Verwandte Kategorien
Allgemeine Beschreibung
Renin, also known as angiotensinogenase, is an aspartyl protease that cleaves angiotensinogen to form angiotensin I, the initial and rate-limiting step of the renin-angiotensin system (RAS). This system plays a critical role in the regulation of blood pressure and fluid balance. Increased renin activity can result in hypertension due to increased vasoconstriction and fluid retention. Inhibitors of renin can be used as a treatment for hypertension.[1]
Eignung
The Renin Assay Kit provides a convenient and simple method for screening renin activity in a variety of samples or for screening renin inhibitors.
Prinzip
Renin activity is determined using a proprietary fluorescence resonance energy transfer (FRET) peptide containing a fluorescence quencher. Cleavage of the peptide by renin results in the production of a fluorescent product (λex = 540/λem = 590 nm). This assay is ~50-fold more sensitive than the EDANS/DABCYL-based assay.
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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American journal of physiology. Heart and circulatory physiology, 310(11), H1671-H1682 (2016-04-10)
Hypertension (HTN) is a major risk factor for heart failure. We investigated the influence of HTN on cardiac contraction and relaxation in transgenic renin overexpressing rats (carrying mouse Ren-2 renin gene, mRen2, n = 6). Blood pressure (BP) was measured.
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Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research (2015)
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Species that this assay works on?
1 answer-
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Does the kit MAK157 contain any Renin inhibitor? If so, how much Renin inhibitor should be added, and at what step of the assay should it be added in order to determine the Renin activity?
1 answer-
The kit MAK157 does not contain any Renin inhibitor. To confirm the activity using this kit, researchers can use a RENIN INHIBITOR separately.The amount of inhibitor to use and the step to use the Renin inhibitor can be referred to from published literature.
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