M3778

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride

Name: N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride
Brand: SIGMA
Price: 143 EUR

≥97% (GC), MAO-A inhibitor, powder

Synonym(e):

Clorgyline

Slide 1 of 3

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

50 MG

€ 143,00

100 MG

€ 264,00

500 MG

€ 858,00

€ 143,00

Warenkorb auf Verfügbarkeit prüfen

Großbestellung anfragen

Über diesen Artikel

Empirische Formel (Hill-System):

C₁₃H₁₅Cl₂NO · HCl

CAS-Nummer:

17780-75-5

Molekulargewicht:

308.63

NACRES:

NA.77

PubChem Substance ID:

24278179

UNSPSC Code:

12352116

EC Number:

241-760-5

MDL number:

MFCD00052012

Assay:

≥97% (GC)

Form:

powder

Quality level:

100

Wichtige Dokumente

Gesamtdokumentation anzeigen

Fortfahren mit

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

Produktname

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride, ≥97% (GC)

Quality Level

100

assay

≥97% (GC)

form

powder

solubility

DMSO: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

Cl.CN(CCCOc1ccc(Cl)cc1Cl)CC#C

InChI

1S/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H

InChI key

BBAZDLONIUABKI-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128)
rat ... Maoa(29253), Maob(25750)

Ähnliche Artikel vergleichen

Vollständigen Vergleich anzeigen

Unterschiede anzeigen

1 of 4

Dieser Artikel	P8511	E2895	A3085
Sigma-Aldrich M3778 N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride	Sigma-Aldrich P8511 trans-2-Phenylcyclopropylamine hydrochloride	Sigma-Aldrich E2895 (±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide	Sigma-Aldrich A3085 5-(N-Ethyl-N-isopropyl)amiloride
form powder	form powder	form powder	form powder
assay ≥97% (GC)	assay ≥97% (TLC)	assay ≥98%	assay ≥98% (TLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL, clear, colorless to faintly yellow	solubility ethanol: 50 mg/mL, clear to slightly hazy	solubility DMSO: 10 mg/mL, clear, colorless to faintly yellow	solubility methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
Gene Information human ... MAOA(4128) rat ... Maoa(29253), Maob(25750)	Gene Information human ... MAOA(4128), MAOB(4129)	Gene Information -	Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553) mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)

Application

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:

in MAO-A biochemical assay[1]
to study its effects on the transit of serotonin (5-HT) in the human placenta explants[2]
to study its effects on human prostate cancer cells[3]

Biochem/physiol Actions

MAO-A inhibitor.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301,H312 + H332

pcodes

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Oral

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.

Tamara Maes et al.

Cancer cell, 33(3), 495-511 (2018-03-06)

The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic

Serotonin synthesis and metabolism-related molecules in a human prostate cancer cell line.

Toshiaki Shinka et al.

Oncology letters, 2(2), 211-215 (2011-03-01)

Prostate cancer is one of the most common tumors in males and its incidence is steadily increasing worldwide. Serotonin or 5-hydroxytryptamine (5-HT) is a well-known neurotransmitter that mediates a wide variety of physiological effects. An increase in the number of

Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities.

J C Shih et al.

Journal of neural transmission. Supplementum, 52, 1-8 (1998-06-13)

MAO-A and -B are defined by their substrate and inhibitor preferences. To determine which regions of the isoenzymes confer these preferences, we have constructed six chimeric MAO enzymes by reciprocally exchanging corresponding N-terminal, C-terminal, and internal segments of MAO-A and

(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies.

Melissa D'Ascenzio et al.

Journal of enzyme inhibition and medicinal chemistry, 30(6), 908-919 (2015-03-26)

Several (thiazol-2-yl)hydrazone derivatives from 2-, 3- and 4-acetylpyridine were synthesized and tested against human monoamine oxidase (hMAO) A and B enzymes. Most of them had an inhibitory effect in the low micromolar/high nanomolar range, being derivatives of 4-acetylpyridine selective hMAO-B

Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.

H Inoue et al.

The Journal of pharmacology and experimental therapeutics, 291(2), 856-864 (1999-10-19)

In an attempt to provide a better understanding of the scope and limitations of animal models used in some drug development programs and to further our understanding of potential metabolic bioactivation reactions, we have undertaken studies to profile the monoamine

Alle zugehörigen Dokumente anzeigen

Artikel

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Global Trade Item Number

SKU	GTIN
M3778-500MG	04061834050605
M3778-100MG	04061834050599
M3778-50MG	04061834050612

Questions

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung

N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride

≥97% (GC), MAO-A inhibitor, powder

Größe auswählen

M3778-50MG

€ 143,00

Über diesen Artikel

Wichtige Dokumente

Fortfahren mit

Eigenschaften

Produktname

Quality Level

assay

form

solubility

storage temp.

SMILES string

InChI

InChI key

Gene Information

Verwandte Kategorien

Ähnliche Artikel vergleichen

Dieser Artikel

Beschreibung

Application

Biochem/physiol Actions

Features and Benefits

Sicherheitshinweise

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Lagerklasse

wgk

ppe

Dokumentation

Analysenzertifikate (COA)

Besitzen Sie dieses Produkt bereits?

Peer-Reviewed-Artikel

Protokolle und Artikel

Artikel

Global Trade Item Number

Questions

Reviews

Active Filters

Technischer Dienst