This item has not been tested for the use in cell culture applications. However, the product has been used successfully by other researchers in a number of publications. Please see the link below to review one example:
Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5058674/
L6402
L-(+)-Milchsäure
BioXtra, ≥98% (titration)
Synonym(e):
(S)-2-Hydroxy-propionsäure
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1 G
€ 55,60
5 G
€ 163,00
10 G
€ 278,00
Über diesen Artikel
Empirische Formel (Hill-System):
C3H6O3
CAS-Nummer:
Molekulargewicht:
90.08
UNSPSC Code:
12161700
NACRES:
NA.25
PubChem Substance ID:
EC Number:
201-196-2
Beilstein/REAXYS Number:
1720251
MDL number:
Assay:
≥98% (titration)
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Unterstützung erhaltenInChI key
JVTAAEKCZFNVCJ-REOHCLBHSA-N
InChI
1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m0/s1
SMILES string
C[C@H](O)C(O)=O
product line
BioXtra
assay
≥98% (titration)
impurities
≤0.005% Phosphorus (P), ≤0.1% Insoluble matter
ign. residue
≤0.1%
solubility
H2O: 1 M at 20 °C, clear, colorless
anion traces
chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%
cation traces
Al: ≤0.0005%, Ca: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%
storage temp.
2-8°C
Quality Level
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98% (titration) | assay - | assay 80% | assay 88-92% total acid basis |
| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. - |
| solubility H2O: 1 M at 20 °C, clear, colorless | solubility - | solubility water: soluble(lit.) | solubility water: soluble(lit.) |
| anion traces chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05% | anion traces - | anion traces chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤100 mg/kg | anion traces chloride (Cl-): ≤50 mg/kg, sulfate (SO42-): ≤100 mg/kg |
| cation traces Ca: ≤0.0005%, Fe: ≤0.0005%, Mg: ≤0.0005%, Na: ≤0.005%, Zn: ≤0.0005%, Al: ≤0.0005%, K: ≤0.005%, Pb: ≤0.001%, Cu: ≤0.0005%, NH4+: ≤0.05% | cation traces - | cation traces Ca: ≤100 mg/kg, Fe: ≤10 mg/kg | cation traces Ca: ≤100 mg/kg, Fe: ≤10 mg/kg |
Biochem/physiol Actions
L-(+)-Milchsäure dient als Substrat für Milchsäure-Dehydrogenase und Laktatoxidase.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1C
supp_hazards
Lagerklasse
8A - Combustible corrosive hazardous materials
wgk
WGK 1
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Melissa M Keenan et al.
PLoS genetics, 11(10), e1005599-e1005599 (2015-10-10)
In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we performed genome-wide
Silvia Selleri et al.
Oncotarget, 7(21), 30193-30210 (2016-04-14)
Human mesenchymal stromal cells (MSC) have been shown to dampen immune response and promote tissue repair, but the underlying mechanisms are still under investigation. Herein, we demonstrate that umbilical cord-derived MSC (UC-MSC) alter the phenotype and function of monocyte-derived dendritic
Koen Poesen et al.
Clinical chemistry and laboratory medicine, 51(7), 1417-1427 (2013-03-16)
With the use of a traditional blood gas analyzer (BGA) (ABL800 Radiometer) for blood glucose monitoring, tight glucose control (TGC) reduced in-hospital mortality and morbidity of surgical intensive care unit (ICU) adult and pediatric patients. Such BGAs are now superseded
David M Garcia et al.
eLife, 5 (2016-12-03)
Robust preference for fermentative glucose metabolism has motivated domestication of the budding yeast Saccharomyces cerevisiae. This program can be circumvented by a protein-based genetic element, the [GAR+] prion, permitting simultaneous metabolism of glucose and other carbon sources. Diverse bacteria can
Markus Dagnell et al.
The Journal of biological chemistry, 294(33), 12330-12338 (2019-06-15)
Protein-tyrosine phosphatases (PTPs) counteract protein tyrosine phosphorylation and cooperate with receptor-tyrosine kinases in the regulation of cell signaling. PTPs need to undergo oxidative inhibition for activation of cellular cascades of protein-tyrosine kinase phosphorylation following growth factor stimulation. It has remained
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Can this product be used for cell culture (mammalian).
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Is this product sterile for biological use (for research)?
1 answer-
This product is tagged as a BioXtra, which means it is intended for biological use, but it is not sterilized. It could be solubilized in sterile, ultrapure water. A sterilized solution such as product 63325 may be more suitable: https://www.sigmaaldrich.com/US/en/product/sial/63325
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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