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L3038

Lysenin from Eisenia foetida

solid

Synonym(e):

Eisenia Lysenin, Lysenin Protein

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PackungsgrößeSKUVerfügbarkeitPreis
50 μg
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€ 585,00

Über diesen Artikel

UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD02687941

€ 585,00

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Unterstützung erhalten

form

solid

Quality Segment

200

mol wt

33 kDa

concentration

≥50% (SDS-PAGE)

storage temp.

−20°C

General description

Lysenin is a superfamily of certain proteins including lysenin-related protein 1 (LRP-1, lysenin 2) and LRP-2 (lysenin 3).

Application

Lysenin from Eisenia foetida has been used to treat B cells and study lysenin′s effect on membrane diacylglycerol (DAG) and surface sphingomyelin (SM).[1]

Biochem/physiol Actions

Lysenin is a 33kDa protein present in the coelomic fluid of the earthworm Eisenia foetida. It interacts with sphingomyelin in cell membranes. In vertebrates, this binding results in cytotoxicity and contraction of smooth muscle in vitro as well as vasodepressor activity and lethality under in vivo conditions.[2]
Lysenin serves as a tool to explore membrane lipid organization.[3] It is known to induce hemolysis in vertebrates and mammalian cells.

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Dieser Artikel
S1135C4063SRP3241
Lysenin from Eisenia foetida solid

Sigma-Aldrich

L3038

Lysenin from Eisenia foetida

Stroma from bovine erythrocytes source of stromal-bound enzymes

Sigma-Aldrich

S1135

Stroma from bovine erythrocytes

C Reactive Protein from human fluids buffered aqueous solution

Sigma-Aldrich

C4063

C Reactive Protein from human fluids

IL-13 Long Form from rat recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sigma-Aldrich

SRP3241

IL-13 Long Form from rat

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

-

form

solid

form

solid

form

buffered aqueous solution

form

lyophilized

mol wt

33 kDa

mol wt

-

mol wt

-

mol wt

12.3 kDa

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

concentration

≥50% (SDS-PAGE)

concentration

-

concentration

-

concentration

-

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
SLCN3549
SLCL8440
SLCL1118
SLCK5598
SLCK0780

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Global Trade Item Number

SKUGTIN
L3038-50UG04061833384992

Questions

  1. What's the solubility of the Lysenin samples in water? I desovate the 50ug sample in 0.6 mL water, looks a lot of not solutable? How to you usaually desovate the samples? In water or any buffers? I am woring on Lysenin reconstitution in to lipid bilyers.

    1 answer

    1. The solubility for the product is not analyzed on a lot to lot basis. However, it has been cited that solution were prepared by dissolving lysenin (1 mg/ml in 2% BSA-PBS) or 50 μg of lysenin in 50 μl of 10 mM HEPES/KOH (pH 7.0) containing 30 mM KCl and 50% Glycerol.

      Kindly review the following citations:
      Yamaji A, Sekizawa Y, Emoto K, Sakuraba H, Inoue K, Kobayashi H, Umeda M. Lysenin, a novel sphingomyelin-specific binding protein. J Biol Chem. 1998 Feb 27;273(9):5300-6. doi: 10.1074/jbc.273.9.5300. PMID: 9478988.

      Faouri RA, Krueger E, Govind Kumar V, Fologea D, Straub D, Alismail H, Alfaori Q, Kight A, Ray J, Henry R, Moradi M, Salamo G. An Effective Electric Dipole Model for Voltage-induced Gating Mechanism of Lysenin. Sci Rep. 2019 Aug 7;9(1):11440. doi: 10.1038/s41598-019-47725-0. PMID: 31391571; PMCID: PMC6686002.

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