L1295

Lamivudin

≥98% (HPLC), nRTI inhibitor, powder

• Synonym(e): 2′,3′-Dideoxy-3′-thiacytidin
• Empirische Formel (Hill-System): C₈H₁₁N₃O₃S
• CAS-Nummer: 134678-17-4
• Molekulargewicht: 229.26
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817388
• NACRES: NA.77
• MDL number: MFCD00869739
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Lamivudin, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: water: 10 mg/mL, clear
• originator: GlaxoSmithKline
• storage temp.: room temp
• SMILES string: NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO)O2
• InChI: 1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
• InChI key: JTEGQNOMFQHVDC-NKWVEPMBSA-N

Beschreibung

Application

Lamivudine has been used to deplete the Hepatitis B Virus (HBV) covalently closed circular DNA (cccDNA) forms for the preparation of inverse nested PCR.

Biochem/physiol Actions

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Warning
• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• target_organs: Blood
• hcodes: H361d,H373,H412
• pcodes: P202 - P260 - P273 - P280 - P308 + P313 - P405
• Hazard Classifications: Aquatic Chronic 3 - Repr. 2 - STOT RE 2