K1514

Kurtoxin

• Empirische Formel (Hill-System): C₃₂₄H₄₇₈N₉₄O₉₀S₈
• Molekulargewicht: 7386.36
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD04119124

Eigenschaften

• form: solid
• Quality Segment: 200
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911) ; mouse ... CACNA1G(12291), CACNA1H(58226), CACNA1I(239556) ; rat ... CACNA1G(29717), CACNA1H(114862), CACNA1I(56827) ;

Beschreibung

General description

Kurtoxin is hydrophobic in nature and shares sequence identity with α-scorpion and has cysteine-stabilized α-helix and β-sheet (CSαβ) motif. It interacts with N-type, and P-type calcium (Ca²⁺) channels as well.

Application

Kurtoxin has been used as a blocker of T-type and R-Type voltage-gated calcium channels (VGGCs) in hippocampal neurons.

Biochem/physiol Actions

Kurtoxin is isolated from the venom of the South African scorpion Parabuthus transvaalicus. It associates with voltage-gated sodium channels and delays their inactivation.

T-type Ca²⁺ channel blocker; Scorpion toxin

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)