This product is not GMP grade. Unfortunately, a GMP grade α-Ketoglutaric acid product is not currently offered. This product is intended for research use only. Unless otherwise stated this product is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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α-Ketoglutarsäure
BioReagent, suitable for cell culture, suitable for insect cell culture
Synonym(e):
2-Oxo-glutarsäure, 2-Oxopentandisäure
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 g | Warenkorb auf Verfügbarkeit prüfen | € 36,90 |
25 g | Warenkorb auf Verfügbarkeit prüfen | € 58,80 |
100 g | Warenkorb auf Verfügbarkeit prüfen | € 199,00 |
Über diesen Artikel
Lineare Formel:
HOOCCH2CH2COCOOH
CAS-Nummer:
Molekulargewicht:
146.10
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
206-330-3
Beilstein/REAXYS Number:
1705689
MDL number:
€ 36,90
Warenkorb auf Verfügbarkeit prüfen
Technischer Dienst
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Unterstützung erhaltenproduct line
BioReagent
Quality Segment
assay
≥98.5% NaOH basis (titration)
form
powder or crystals
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
solubility
water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless
storage temp.
2-8°C
SMILES string
OC(=O)CCC(=O)C(O)=O
InChI
1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChI key
KPGXRSRHYNQIFN-UHFFFAOYSA-N
General description
Alpha-ketoglutarate (αKG), a vital intermediate in the tricarboxylic acid (TCA)/Krebs cycle, is located between succinyl-CoA and isocitrate.[1]
Application
α-Ketoglutaric acid has been used:
- as a supplement in minimum essential medium α (α-MEM) to culture primary mesenchymal stromal/stem cells (MSCs) to study its effects on age-related osteoporosis[1]
- for chemical treatments to compare the treatment effects of several compounds on lifespan between manual and automated lifespan machine (ALM) platforms[2]
- as a printed chemotaxis ligand to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR)[3]
Biochem/physiol Actions
Alpha-ketoglutarate (αKG), a nitrogen scavenger, is an important source of glutamate and glutamine.[4] It controls the synthesis of ATP and decreases the generation of equivalent (NAD+/NADH) in the tricarboxylic acid (TCA) cycle.[1] It promotes the synthesis of protein and prevents protein degradation in muscles. This immune nutrient factor participates in the general immune and collagen metabolism.[4] In aged rodents, αKG accelerates the healing of bone defects. It may possess potential anti-aging effects.[1] This Krebs cycle molecule can be used as a supplement in insect and mammalian cell cultures.
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98.5% NaOH basis (titration) | assay ≥98.5% (NaOH, titration) | assay 99.0-101.0% (T) | assay ≥97% (HPLC) |
| solubility water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless | solubility water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility H2O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless | solubility H2O: 100 mg/mL |
| technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| form powder or crystals | form powder | form crystals | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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