I8021

L-N⁶-(1-Iminoethyl)lysine dihydrochloride

• Synonym(e): L-Lysine ω-acetamidine dihydrochloride, L-NIL dihydrochloride
• Empirische Formel (Hill-System): C₈H₁₇N₃O₂ · 2 HCl
• CAS-Nummer: 159190-45-1
• Molekulargewicht: 260.16
• NACRES: NA.77
• PubChem Substance ID: 24278827
• UNSPSC Code: 12352209
• MDL number: MFCD00270890
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• biological source: synthetic (organic)
• assay: ≥97% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
• InChI: 1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
• InChI key: OQIBCXRAFAHXMM-KLXURFKVSA-N
• Gene Information: human ... NOS2(4843)

Beschreibung

Application

L-N⁶-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:

• to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
• to study its effects on leptin-induced inflammation in hepatocytes
• to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)

Biochem/physiol Actions

Selective inhibitor of inducible nitric oxide synthase (iNOS).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves