I3159

IMD-0354

≥98% (HPLC), solid

• Synonym(e): N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide
• Empirische Formel (Hill-System): C₁₅H₈ClF₆NO₂
• CAS-Nummer: 978-62-1
• Molekulargewicht: 383.67
• MDL-Nummer: MFCD00218820
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724513
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Löslichkeit: DMSO: >20 mg/mL
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
• InChI: 1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
• InChIKey: CHILCFMQWMQVAL-UHFFFAOYSA-N

Beschreibung

Anwendung

IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.

Biochem./physiol. Wirkung

IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. ^[4]

Verpackung

Light sensitive. Packaged under nitrogen.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves