I0514

Isocyanmethylphosphonsäure-diethylester

>97% (GC)

• Synonym(e): Diethylisocyanomethylphosphonat, Isocyanmethanphosphonsäure-diethylester
• Lineare Formel: CNCH₂P(O)(OC₂H₅)₂
• CAS-Nummer: 41003-94-5
• Molekulargewicht: 177.14
• Beilstein: 4674920
• MDL-Nummer: MFCD00042951
• UNSPSC-Code: 12352000

Eigenschaften

• Assay: >97% (GC)
• Brechungsindex: n20/D 1.433 (lit.)
• bp: 84-87 °C/0.1 mmHg (lit.)
• Dichte: 1.105 g/mL at 25 °C (lit.)
• Lagertemp.: 2-8°C
• SMILES String: CCOP(=O)(C[N+]#[C-])OCC
• InChI: 1S/C6H12NO3P/c1-4-9-11(8,6-7-3)10-5-2/h4-6H2,1-2H3
• InChIKey: ICURVXBGGDVHDT-UHFFFAOYSA-N

Beschreibung

Anwendung

Reactant for:

• Copper-catalyzed cycloaddition reactions
• Preparation of orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase
• Synthesis of sterol analogs as antifungal agents against plant pathogens
• Asymmetric synthesis of steroidal 2,5-diketopiperazines prepared via isocyanide chemistry based on stereoselective Ugi four component condensation and subsequent cyclocondensation reactions
• The Passerini reaction

Precursor for synthesis of phosphonic acid analogs of α-amino acids.