H9786
Anti-Hepatocyte Growth Factor Receptor (c-Met) antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(e):
Anti-HGF Receptor
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About This Item
Biologische Quelle
goat
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
lyophilized powder
Speziesreaktivität
human
Methode(n)
flow cytometry: suitable
immunohistochemistry: 5-15 μg/mL
western blot: 0.1-0.2 μg/mL
Verunreinigungen
endotoxin, tested
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... MET(4233)
mouse ... Met(17295)
Allgemeine Beschreibung
The antibody neutralizes receptor-ligand interaction. At 0.5-2 μg/mL the antibody will block 50% of the binding of 5 ng/mL recombinant human HGF to 0.1 μg immobilized recombinant human HGF R/c-MET Fc chimera. >90% of the binding will be blocked by 10 μg/mL of the antibody.
Immunogen
purified recombinant human hepatocyte growth factor receptor extracellular domain expressed in mouse NSO cells.
Anwendung
Anti-Hepatocyte Growth Factor Receptor (c-Met) antibody produced in goat was used to block c-Met in HeLa cells.
Biochem./physiol. Wirkung
Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Hedwig S Kruitwagen et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(7), 940-949 (2011-07-08)
Although the liver has a large regenerative capacity, in many hepatopathies, these repair mechanisms fail. The therapeutic potential of hepatocyte growth factor (HGF) has been proven in numerous toxin-induced liver failure models in rodents, but never in spontaneously occurring liver
Simone Buraschi et al.
The Journal of biological chemistry, 285(53), 42075-42085 (2010-10-27)
A theme emerging during the past few years is that members of the small leucine-rich proteoglycan gene family affect cell growth by interacting with multiple receptor tyrosine kinases (RTKs), mostly by a physical down-regulation of the receptors, thereby depriving tumor
Jesus Pérez-Hernández et al.
Life (Basel, Switzerland), 11(9) (2021-09-29)
Amoebiasis in humans is caused by the protozoan parasite Entamoeba histolytica, which cytotoxic activity has been demonstrated on a wide variety of target cells. The process involves the adherence of the parasite to the cell, and such adherence is mediated
K Matsumoto et al.
Critical reviews in oncogenesis, 3(1-2), 27-54 (1992-01-01)
Hepatocyte growth factor (HGF) is the most potent mitogen for mature hepatocytes and seems to act as a hepatotropic factor that has not been purified over the past 30 years. HGF was first purified from rat platelets in 1986. HGF
Shinya Mizuno et al.
Frontiers in bioscience : a journal and virtual library, 13, 7072-7086 (2008-05-30)
Hepatocyte growth factor (HGF) and Met/HGF receptor play roles in dynamic growth and morphogenesis during development and regeneration of organs, including the kidney. In the kidney, HGF targets different types of cells, while its biological actions depend on a target
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