G6793

GW7647

≥98% (HPLC), Potent human PPARα agonist

• Synonym(e): 2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)­phenyl­thio)-2-methyl­propionic acid
• Empirische Formel (Hill-System): C₂₉H₄₆N₂O₃S
• CAS-Nummer: 265129-71-3
• Molekulargewicht: 502.75
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278790
• NACRES: NA.77
• MDL number: MFCD06798379
• Assay: ≥98% (HPLC)

Eigenschaften

• Produktname: GW7647, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• color: white
• solubility: DMSO: soluble 16 mg/mL, H₂O: insoluble
• SMILES string: CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O
• InChI: 1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
• InChI key: PKNYXWMTHFMHKD-UHFFFAOYSA-N
• Gene Information: human ... PPARA(5465)

Beschreibung

Application

GW7647 has been used as a peroxisome proliferator-activated receptor α (PPAR α) ligand:

• in defatting medium to treat primary human hepatocytes
• to test its effect on the glycolytic function in cardiomyocytes
• to test its effect on infant mouse heart
• in breast cancer MDA-MB-231 cells to activate PPARs

Biochem/physiol Actions

GW7647 reduces serum triglyceride levels and enhances hepatic expression of genes associated with β-oxidation. Usage of GW7647 along with metformin in conditions of liver steatosis or injury improves the enzymatic levels of aspartate transaminase (AST) and alanine transaminase (ALT) in serum.

Potent human PPARα agonist. Use to study the biology of PPARα receptor in human cells.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes only under agreement from Glaxo­Smith­Kline

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)