G2911

Bisindolylmaleimide I

synthetic, ≥90% (HPLC)

• Synonym(e): 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I
• Empirische Formel (Hill-System): C₂₅H₂₄N₄O₂
• CAS-Nummer: 133052-90-1
• Molekulargewicht: 412.48
• UNSPSC Code: 12352202
• PubChem Substance ID: 329799908
• NACRES: NA.77
• MDL number: MFCD00236428
• Assay: ≥90% (HPLC)

Eigenschaften

• Produktname: GF 109203X, synthetic, ≥90% (HPLC)
• biological source: synthetic
• Quality Segment: 100
• assay: ≥90% (HPLC)
• solubility: DMSO: soluble (~1 mg/ml)
• storage temp.: 2-8°C
• SMILES string: CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15
• InChI: 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
• InChI key: QMGUOJYZJKLOLH-UHFFFAOYSA-N

Beschreibung

Application

GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.

Biochem/physiol Actions

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca²⁺ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca²⁺ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.

Preparation Note

For PKC inhibition, typically used at a concentration of 0.1-10 μM.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• Gefahrencodes: H350
• Sicherheitshinweise: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 1B
• supp_hazards: EUH019
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects