G1918

Gö 6983

≥97%, PKC inhibitor, powder

• Synonym(e): 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
• Empirische Formel (Hill-System): C₂₆H₂₆N₄O₃
• CAS-Nummer: 133053-19-7
• Molekulargewicht: 442.51
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894916
• NACRES: NA.77
• MDL number: MFCD04040031
• Assay: ≥97%
• Form: powder

Eigenschaften

• Produktname: Gö 6983, ≥97%
• Quality Segment: 100
• assay: ≥97%
• form: powder
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1
• InChI: 1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
• InChI key: LLJJDLHGZUOMQP-UHFFFAOYSA-N

Beschreibung

Application

GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).

Biochem/physiol Actions

Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC₅₀ = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC₅₀ = 20 mM).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves