FLAAS

Adenosine 5′-triphosphate (ATP) disodium salt hydrate

≥90%, bacterial (Corynebacterium sp), lyophilized powder

• Synonym(e): ATP disodium hydrate
• Lineare Formel: C₁₀H₁₄N₅O₁₃P₃Na₂ · xH₂O
• CAS-Nummer: 34369-07-8
• Molekulargewicht: 551.14 (anhydrous basis)
• eCl@ss: 32160414
• PubChem Substance ID: 24895005
• NACRES: NA.26
• EC Number: 213-579-1
• MDL number: MFCD00150755
• UNSPSC Code: 12352208
• Assay: ≥90%
• Biological source: bacterial (Corynebacterium sp)
• Form: lyophilized powder
• Solubility: water: soluble, clear, colorless (1 vial + 0.1 mL)
• Storage temp.: −20°C

Eigenschaften

• Produktname: Adenosine 5′-triphosphate (ATP) disodium salt hydrate, vial of ~1 mg ATP
• biological source: bacterial (Corynebacterium sp)
• Quality Segment: 200
• assay: ≥90%
• form: lyophilized powder
• packaging: vial of ~1 mg ATP
• solubility: water: soluble, clear, colorless (1 vial + 0.1 mL)
• storage temp.: −20°C
• SMILES string: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
• InChI key: NTBQNWBHIXNPRU-MSQVLRTGSA-L

Beschreibung

Application

Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been:

• used as a standard to measure ATP by bioluminescence method[1]
• used in kinase buffer to assess the interaction between death-associated protein kinases (DAPK2) and 14-3-3-β
• used as a standard in ATP colorimetric assay

Biochem/physiol Actions

Adenosine 5′-triphosphate was shown to have inhibitory effects on the inflammatory response by abrogating secretion of TNF-α and promoting secretion of Interleukin-10. [2]

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems

Adenosine 5′-triphosphate (ATP) is one of the nucleoside triphosphate present in living system. It controls various biologic processes such as glucose metabolism, muscle contraction and neurotransmission. Apart from this, ATP serves as an important energy source for the cell. Administration of ATP might be useful in the treatment of non-small-cell lung cancer.

Preparation Note

Each vial contains ~1.2 mg of Na₂ATP • 3H₂O equivalent to ~1.0 mg of ATP (2.0 μmol). Actual amount printed on the label.

Prepared to be substantially vanadium-free.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)