F5130

5-Fluoruridin

≥99% (HPLC), synthetic (organic), powder

• Synonym(e): 5-Fluor-uracil-1β-D-ribofuranosid, FUrd
• Empirische Formel (Hill-System): C₉H₁₁FN₂O₆
• CAS-Nummer: 316-46-1
• Molekulargewicht: 262.19
• NACRES: NA.51
• PubChem Substance ID: 24894883
• UNSPSC Code: 41106305
• EC Number: 206-260-3
• MDL number: MFCD00036832
• Beilstein/REAXYS Number: 33662
• Assay: ≥99% (HPLC)
• Biological source: synthetic (organic)
• Form: powder
• Solubility: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

Eigenschaften

• Produktname: 5-Fluoruridin, proapoptotic anitproliferative plant growth regulator
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥99% (HPLC)
• form: powder
• solubility: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=C(F)C(=O)NC2=O
• InChI: 1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
• InChI key: FHIDNBAQOFJWCA-UAKXSSHOSA-N

Beschreibung

General description

5-Fluorouridine (FUrd) is a fluoropyrimidine nucleoside analog and a cell-permeable modified RNA precursor.[1]

Application

5-Fluorouridine has been used for labeling active transcription sites in the porcine fetal fibroblasts[1] and human cell lines for immunocytochemistry analysis.[2] It has also been used to monitor apoptosis during drug sensitivity assay in esophageal squamous cell carcinoma (ESCC) cells.[3]

Biochem/physiol Actions

5-Fluorouridine (FUrd) is cytotoxic towards cancer cells. FUrd is often used in chemical and biochemical comparison studies with fluorouracil and thymine analogs.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves