E3888

[D-Pen^2,5]-Enkephalin hydrate

≥95% (HPLC)

• Synonym(e): DPDPE
• Empirische Formel (Hill-System): C₃₀H₃₉N₅O₇S₂ · xH₂O
• Molekulargewicht: 645.79 (anhydrous basis)
• NACRES: NA.32
• PubChem Substance ID: 329799055
• UNSPSC Code: 12352209
• MDL number: MFCD00076430

Eigenschaften

• Quality Segment: 200
• assay: ≥95% (HPLC)
• storage temp.: −20°C
• SMILES string: CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H]1C(O)=O
• InChI: 1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
• InChI key: MCMMCRYPQBNCPH-WMIMKTLMSA-N

Beschreibung

General description

[D-Pen^2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist.[1] Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.[2]

Application

[D-Pen^2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents.[3] It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).[4]

Biochem/physiol Actions

Antinociceptive activity mediated through the δ₁ receptor while the modulatory activity is mediated through the δ₂ receptor. Tritiated [D-Pen^2,5]-enkephalin is used as a δ₁ ligand.

Other Notes

Lyophilized from 0.1% TFA in H2O

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)