E2643

Enterostatin human

≥97% (HPLC)

• Empirische Formel (Hill-System): C₂₁H₃₆N₈O₆
• CAS-Nummer: 117830-79-2
• Molekulargewicht: 496.56
• UNSPSC Code: 51111800
• PubChem Substance ID: 329799035
• MDL number: MFCD00133052

Eigenschaften

• Produktname: Enterostatin human, ≥97% (HPLC)
• InChI: 1S/C21H36N8O6/c1-12(22)19(33)29-10-4-6-14(29)17(31)26-11-16(30)28-9-3-7-15(28)18(32)27-13(20(34)35)5-2-8-25-21(23)24/h12-15H,2-11,22H2,1H3,(H,26,31)(H,27,32)(H,34,35)(H4,23,24,25)/t12-,13-,14-,15-/m0/s1
• SMILES string: C[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
• InChI key: ITZMJCSORYKOSI-AJNGGQMLSA-N
• assay: ≥97% (HPLC)
• UniProt accession no.: P04118
• storage temp.: −20°C
• Gene Information: human ... CLPS(1208)

Beschreibung

Application

Enterostatin human maybe used to study the hydrolytic activity of human angiotensin-converting enzyme-related carboxypeptidase (ACE2) on human biological peptides.[1]

Biochem/physiol Actions

Peptide that inhibits fat intake in experiments involving dietary choice.

Studies show that peripheral and central injection of enterostatin reduces the food intake. In Sprague-Dawley rats, central injection leads to a reduction in the intake of high-fat food as opposed to low-fat food. Therefore, it might have a role in the feedback loop of dietary fat.[2] In a chronic manner, it is responsible for the reduction of body fat, intake of fat and body weight.[3] It controls the secretory activity of β-cells of pancreas, and suppresses insulin secretion without affecting the secretion of glucagon and somatostatin. It might also have anti-incretin activity in the enteroinsular axis, and might regulate postprandial hyperinsulinemia.[4]

General description

Enterostatin is a pentapeptide Val-Pro-Asp-Pro-Arg (VPDPR) obtained from trypsin digestion of procolipase, which is a pancreatic lipase.[2] It is produced by the intestine, and the gastric mucosa.[3]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)