D9439

Desmosine chloride

from bovine, 99.5%±0.2%

• Synonym(e): DES
• Empirische Formel (Hill-System): C₂₄H₄₀ClN₅O₈
• CAS-Nummer: 10019-68-8
• Molekulargewicht: 562.06
• NACRES: NA.56
• PubChem Substance ID: 329798901
• UNSPSC Code: 12352202
• MDL number: MFCD12910449
• Form: lyophilized powder
• Assay: 99.5%±0.2%
• Biological source: bovine

Eigenschaften

• biological source: bovine
• Quality Level: 100
• assay: 99.5%±0.2%
• form: lyophilized powder
• purified by: chromatography (and purified by solvent extraction)
• storage temp.: 2-8°C
• SMILES string: [Cl-].NC(CCCC[n+]1cc(CCC(N)C(O)=O)c(CCCC(N)C(O)=O)c(CCC(N)C(O)=O)c1)C(O)=O
• InChI: 1S/C24H39N5O8.ClH/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37;/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37);1H
• InChI key: FUPMLZCXPJSGPV-UHFFFAOYSA-N

Beschreibung

General description

Each vial contains 1 μmole of purified desmosine.

Application

Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema). Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).

Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.

Biochem/physiol Actions

Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.

Analysis Note

Calibrated by UV and amino acid analysis.

Disclaimer

Extremely hygroscopic

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)