D8946

DMH1

≥98% (HPLC), powder, BMP inhibitor

• Synonym(e): 4-[6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
• Empirische Formel (Hill-System): C₂₄H₂₀N₄O
• CAS-Nummer: 1206711-16-1
• Molekulargewicht: 380.44
• UNSPSC Code: 51111800
• PubChem Substance ID: 329798883
• NACRES: NA.77
• MDL number: MFCD18384963
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated

Eigenschaften

• Produktname: DMH1, ≥98% (HPLC)
• SMILES string: CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3
• InChI key: JMIFGARJSWXZSH-UHFFFAOYSA-N
• InChI: 1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: light yellow to orange
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• Quality Level: 100

Beschreibung

General description

DMH1 stimulates neurogenesis of human-induced pluripotent stem cells (hiPSCs) and suppresses the growth and metastasis of lung cancer. It blocks cellular autophagy responses.[1]

Application

DMH1 has been used for bone morphogenetic protein (BMP) inhibition.[2][3] [4]

Biochem/physiol Actions

DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor.

DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH1 is a dorsomorphin analogue that exclusively targets the BMP but not the VEGF pathway.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable