D8008
7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
≥95%
Synonym(e):
DEDA
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Empirische Formel (Hill-System):
C22H40O2
CAS-Nummer:
Molekulargewicht:
336.55
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
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Unterstützung erhaltenTechnischer Dienst
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Unterstützung erhaltenInChI
1S/C22H40O2/c1-4-5-6-7-8-9-10-11-12-13-16-19-22(2,3)20-17-14-15-18-21(23)24/h16-17,19-20H,4-15,18H2,1-3H3,(H,23,24)/b19-16-,20-17-
SMILES string
CCCCCCCCCCC\C=C/C(C)(C)\C=C/CCCC(O)=O
InChI key
AGKRHAILCPYNFH-DUQSFWPASA-N
biological source
synthetic (organic)
assay
≥95%
form
liquid
storage temp.
−20°C
Gene Information
human ... ADORA2A(135), ADORA2B(136)
Biochem/physiol Actions
Inhibitor of phospholipase A2 and lipoxygenase. Inhibits endogenous synthesis of leukotrienes.
Lagerklasse
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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D G Johns et al.
The American journal of physiology, 275(5 Pt 2), H1592-H1598 (1998-11-14)
Ceramide is a novel second messenger generated by hydrolysis of membrane sphingomyelin by a neutral sphingomyelinase (nSMase). Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been shown to increase intracellular ceramide through phospholipase A2 (PLA2)-dependent activation of nSMase. TNF-alpha has
C S Ramesha et al.
Analytical biochemistry, 192(1), 173-180 (1991-01-01)
a simple gas chromatographic method for the assay of phospholipase A2 (PLA2) has been described in which arachidonic acid released from endogenous phospholipid pools is measured following its extraction and derivatization to pentafluorobenzyl esters. Using this assay, PLA2 activities in
Yinchun Jiao et al.
Molecules (Basel, Switzerland), 25(18) (2020-09-10)
We show that natural bond orbital (NBO) and natural resonance theory (NRT) analysis methods provide both optimized Lewis-structural bonding descriptors for ground-state electronic properties as well as suitable building blocks for idealized "diabatic" two-state models of the associated spectroscopic excitations.
S Giri et al.
Journal of lipid research, 47(7), 1478-1492 (2006-04-29)
Globoid cell leukodystrophy (Krabbe disease) is an inherited neurological disorder caused by the pathogenomic accumulation of psychosine (galactosylsphingosine), a substrate for the deficient enzyme galactocerebroside beta-galactosidase. This study underscores the mechanism of action of psychosine in the regulation of oligodendrocyte
Jannike M Andersen et al.
Neurochemical research, 28(2), 319-326 (2003-03-01)
In this paper we show that exposure of a rat brain synaptosome fraction to the amyloid beta peptide fragment betaA(25-35), but not the inverted peptide betaA(35-25), stimulated production of reactive oxygen species (ROS) in a concentration- and time-dependent manner. The
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