D5569

DCHC

≥98% (HPLC), solid

• Synonym(e): 3-(2,4-Dichlorophenyl)-7-hydroxy-4H-chromen-4-one
• Empirische Formel (Hill-System): C₁₅H₈Cl₂O₃
• CAS-Nummer: 302953-06-6
• Molekulargewicht: 307.13
• NACRES: NA.77
• PubChem Substance ID: 329798809
• UNSPSC Code: 12352202
• MDL number: MFCD01848896
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• assay: ≥98% (HPLC)
• form: solid
• color: yellow
• solubility: DMSO: >20 mg/mL
• SMILES string: Oc1ccc2C(=O)C(=COc2c1)c3ccc(Cl)cc3Cl
• InChI: 1S/C15H8Cl2O3/c16-8-1-3-10(13(17)5-8)12-7-20-14-6-9(18)2-4-11(14)15(12)19/h1-7,18H
• InChI key: QMSGNLMBWFRALO-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

DCHC is a SIRT1 activator. It increases peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) expression, resulting in mitochondrial biogenesis.

DCHC is a SIRT1 activator. It increases peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) expression, resulting in mitochondrial biogenesis. DCHC activates SIRT1 at low micromolar concentrations (5–10 μM) and increases SIRT1 activity at 100 μM. It is different from 5,7,4′-T in that it induces the activation of recombinant SIRT1, but does not increase SIRT1 expression.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges