D3321

Dipeptidyl Peptidase VII human

recombinant, expressed in Sf9 cells

• Synonym(e): DPP7, Quiescent cell proline dipeptidase
• EC-Nummer: 3.4.14.-
• UNSPSC-Code: 12352204
• NACRES: NA.54

Eigenschaften

• Rekombinant: expressed in Sf9 cells
• Qualitätsniveau: 200
• Form: solution
• Spezifische Aktivität: ≥1,500 units/μg protein; ≥1500 units/μg protein
• Mol-Gew.: 89.1 kDa
• Relevante Krankheit(en): diabetes; cardiovascular diseases
• Versandbedingung: dry ice
• Lagertemp.: −70°C

Beschreibung

Anwendung

Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes [1]. DPP7 is used to study the regulation of cell quiescence [2]. Like DPP4, DPP7 may be useful in diabetes and vascular disease research [3].

Biochem./physiol. Wirkung

DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 [2]. DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.

Physikalische Eigenschaften

Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa

Einheitendefinition

One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C

Physikalische Form

Supplied as a solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol.

Sicherheitshinweise

• Piktogramme: GHS08,GHS05
• Signalwort: Danger
• H-Sätze: H314,H360D
• P-Sätze: P202 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Gefahreneinstufungen: Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2