CN406-05

Canine Osteoblasts: CnOb (Cryovial)

• NACRES: NA.81
• UNSPSC Code: 41106514
• Biological source: canine bone (normal)
• Growth mode: Adherent
• Morphology: osteoblast
• Relevant disease(s): arthritis; osteoporosis

Eigenschaften

• biological source: canine bone (normal)
• packaging: pkg of 500,000 cells
• manufacturer/tradename: Cell Applications, Inc
• growth mode: Adherent
• karyotype: 2n = 78
• morphology: osteoblast
• technique(s): cell culture | mammalian: suitable
• relevant disease(s): arthritis; osteoporosis
• shipped in: dry ice
• storage temp.: −196°C

Beschreibung

General description

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Canine osteoblasts provide an excellent model system for studies relevant to the skeletal system, including mechanisms of cancerogenesis.

Canine osteoblasts have been used to define a biomarker profile of canine osteosarcoma (Milovancev, 2013), elucidate the roles of oncogenic STAT3 (Fossey, 2009, 2011) and canonical Wnt signaling (Piskun, 2013) pathways, and to develop personalized osteosarcoma treatments by testing Src inhibitor dasatinib (Davis, 2013), procaspase-3 activating compound PAC-1 (Book, 2012), HSP90 inhibitor STA-1474 (McCleese, 2009) and STAT3 inhibitor LLL12 (Couto, 2012, 2013).

Characterization: Positive for bone mineralization.

Application

model for skeletal system research, signaling pathways, bone morphogenesis, gene expression, cell activation and proliferation, wound healing, bone formation and regeneration, treatment strategies, tissue engineering, in vitro bone models, mineralization, hormone treatments

Biochem/physiol Actions

Bone

Preparation Note

• 1st passage, >500,000 cells in Canine Osteoblast Basal Medium containing 10% FBS & 10% DMSO
• Can be cultured at least 10 doublings

Please refer to the CnOb Culture Protocol.

Other Notes

Canine Osteoblast Basal Medium containing 10% FBS & 10% DMSO

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable