C7743

CHPG

≥98% (HPLC), white, solid

• Synonym(e): α-amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
• Empirische Formel (Hill-System): C₈H₈ClNO₃
• CAS-Nummer: 170846-74-9
• Molekulargewicht: 201.61
• NACRES: NA.77
• PubChem Substance ID: 329775148
• UNSPSC Code: 12352200
• MDL number: MFCD01321059
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Eigenschaften

• InChI: 1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
• SMILES string: NC(C(O)=O)c1cc(O)ccc1Cl
• InChI key: UNIDAFCQFPGYJJ-UHFFFAOYSA-N
• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• color: white
• solubility: DMSO: ≥10 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

CHPG is a selective, potent mGluR5 agonist.

CHPG is a selective, potent mGluR5 agonist. CHO cells expressing mGluR5 (but not those expressing mGluR1) are activated by CHPG. In vivo, CHPG stimulates thalamic neurons and is antagonized by MPEP (selective mGluR5 antagonist); CHPG potentiates NMDA and AMPA responses in spinal cord and produces oscillations in intracellular calcium in dorsal root ganglion cells.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves